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Exploring computational and mathematical biology at McGill University.

Research Frontiers

Bridging computation and biology through innovative modeling

Active Research Projects

Our research spans mathematical and computational biology with an emphasis on complex systems, nonlinear and stochastic dynamics, biophysics, and artificial intelligence. We study various physiological systems in neuroscience, immunology, and cell biology. Current project themes in collaboration with experimental labs include:

Neural Dynamics & Circuits

Decoding ion channel regulation and network-level rhythms through biophysical models

#Excitability #CalciumSignaling

Adaptive Immune Responses

Modeling T cell activation dynamics and population-level decision making

#NanoparticleActivation #MigrationPatterns

Quantitative Biology

Computational modeling of biological systems such as protein networks and cell migration.

#DeepLearning #StochasticModeling

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Selected Publications

Recent research contributions from our lab

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics

Koch, N. A., Corrigan, B. W., Feyerabend, M., Gulli, R. A., Jimenez-Sosa, M. S., Abbass, M., ... & Martinez-Trujillo, J. C.

Cell Reports, 2025

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A neurophysiological basis for aperiodic EEG and the background spectral trend

Brake, N., Duc, F., Rokos, A., Arseneau, F., Shahiri, S., Khadra, A., & Plourde, G.

Nature communications, 2024

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Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity

Jamaleddine, H., Rogers, D., Perreault, G., Postat, J., Patel, D., Mandl, J. N., & Khadra, A.

Plos Biology, 2024

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Modulation of SK channels via calcium buffering tunes intrinsic excitability of parvalbumin interneurons in neuropathic pain: A computational and experimental investigation

Ma, X., Miraucourt, L. S., Qiu, H., Sharif-Naeini, R., & Khadra, A.

Journal of Neuroscience, 2023

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Lab News

March 14, 2025

New paper accepted in iScience

Our latest manuscript in collaboration with Chacron's lab and Bashivan's lab on neural correlates of invariant coding has been accepted in iScience.

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January 30, 2025

New paper accepted in Nature

Our latest manuscript in collaboration with Bowie's lab on neural excitability patterns has been accepted in Nature.

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February 15, 2025

New paper accepted in Plos Computational Biology

Our latest manuscript on the contribution of action potential to EEG has been accepted in Plos Computational Biology.

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June 20, 2024

Conference Presentation at SMB 2024

Dr. Khadra delivered a talk on the Calcium dynamics in Oligodendrocytes at Annual Meeting of Society for Mathematical Biology.

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April 10, 2024

New Grant Awarded

Our lab received a prestigious grant from Natural Sciences and Engineering Research Council of Canada (NSERC)

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