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Exploring computational and mathematical biology at McGill University.

Research Frontiers

Bridging computation and biology through innovative modeling

Active Research Projects

Our research spans mathematical and computational biology with an emphasis on complex systems, nonlinear and stochastic dynamics, biophysics, and artificial intelligence. We study various physiological systems in neuroscience, immunology, and cell biology. Current project themes in collaboration with experimental labs include:

Neural Dynamics & Circuits

Decoding ion channel regulation and network-level rhythms through biophysical models

#Excitability #CalciumSignaling

Adaptive Immune Responses

Modeling T cell activation dynamics and population-level decision making

#NanoparticleActivation #MigrationPatterns

Quantitative Biology

Computational modeling of biological systems such as protein networks and cell migration.

#DeepLearning #StochasticModeling

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Selected Publications

Recent research contributions from our lab

A neurophysiological basis for aperiodic EEG and the background spectral trend

Niklas Brake and Flavie Duc and Alexander Rokos and Francis Arseneau and Shiva Shahiri and Anmar Khadra and Gilles Plourde

Nature communications, 2024

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Modulation of SK channels via calcium buffering tunes intrinsic excitability of parvalbumin interneurons in neuropathic pain: A computational and experimental investigation

Xinyue Ma and Loïs S Miraucourt and Haoyi Qiu and Reza Sharif-Naeini and Anmar Khadra

Journal of Neuroscience, 2023

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Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity

Hassan Jamaleddine and Dakota Rogers and Geneviève Perreault and Jérémy Postat and Dhanesh Patel and Judith N Mandl and Anmar Khadra

Plos Biology, 2024

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Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics

Nils A Koch and Benjamin W Corrigan and Michael Feyerabend and Roberto A Gulli and Michelle S Jimenez-Sosa and Mohamad Abbass and Julia K Sunstrum and Sara Matovic and Megan Roussy and Rogelio Luna and Samuel A Mestern and Borna Mahmoudian and Susheel Vijayraghavan and Hiroyuki Igarashi and Kartik S Pradeepan and William J Assis and J Andrew Pruszynski and Shreejoy Tripathy and Jochen F Staiger and Guillermo Gonzalez-Burgos and Andreas Neef and Stefan Treue and Stefan Everling and Wataru Inoue and Anmar Khadra and Julio C Martinez-Trujillo

Cell Reports, 2025

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Lab News

Recent happenings and announcements from our lab

April 24, 2026

Ryan Huang Receives NSERC Doctoral Award

Congratulations to PhD student Ryan Huang for receiving the prestigious NSERC doctoral award (PGS-D) for 2026–2029, as well as the Faculty of Medicine Graduate Fellowship.

Award

April 20, 2026

Mackey-Glass & CAMBAM Student Awards

Congratulations to Adrian Yehia for receiving the Mackey-Glass Undergraduate Award (2026), and to Yifan Zhao for receiving the CAMBAM Undergraduate Fellowship (2026).

Award

April 5, 2026

New Publication in Immunology and Cell Biology

Louis Richez and Dr. Khadra published a new study titled "The Geometry of pMHC-Coated Nanoparticles and T Cell Receptor Clusters Governs the Sensitivity-Specificity Trade-off in T Cell Response: A Modeling Investigation" in Immunology and Cell Biology.

Publication

April 1, 2026

New Publication in Journal of Computational Neuroscience

Nils Koch, Yifan Zhao, and Dr. Khadra published a new study titled "Dendritic Interaction of Timescales in Afterdepolarization Potentials and Nonmonotonic Spike-Adding" in the Journal of Computational Neuroscience.

Publication

March 15, 2026

Invited Talk at Brandeis University

Dr. Khadra delivered an invited seminar titled "Intrinsic Dynamics Under Synaptic Bombardment: Mechanisms of Burst Firing and Spiking Heterogeneity In Vivo" at the Department of Mathematics, Brandeis University, USA.

Conference

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