The geometry of pMHC-coated nanoparticles and T-cell receptor clusters governs the sensitivity-specificity trade-off in T-cell response: a modeling investigation.

Louis Richez and Anmar Khadra

Immunology and Cell Biology, 2026

Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention

Jonas Lehnert and Kuwook Cha and Julia Forestell and Kerry Yang and Xinyue Ma and Sinan Shariff and Jonathan Britt and Anmar Khadra and Erik P Cook and Arjun Krishnaswamy

Nature Communications, 2026

Dendritic Interaction of Timescales in Afterdepolarization Potentials and Nonmonotonic Spike-Adding

Nils A. Koch and Yifan Zhao and Anmar Khadra

Journal of Computational Neuroscience, 2026

Contributions of action potentials to scalp EEG: theory and biophysical simulations

Niklas Brake and Anmar Khadra

PLOS Computational Biology, 2025

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics

Nils A Koch and Benjamin W Corrigan and Michael Feyerabend and Roberto A Gulli and Michelle S Jimenez-Sosa and Mohamad Abbass and Julia K Sunstrum and Sara Matovic and Megan Roussy and Rogelio Luna and Samuel A Mestern and Borna Mahmoudian and Susheel Vijayraghavan and Hiroyuki Igarashi and Kartik S Pradeepan and William J Assis and J Andrew Pruszynski and Shreejoy Tripathy and Jochen F Staiger and Guillermo Gonzalez-Burgos and Andreas Neef and Stefan Treue and Stefan Everling and Wataru Inoue and Anmar Khadra and Julio C Martinez-Trujillo

Cell Reports, 2025

Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations

Michael G Metzen and Amin Akhshi and Pouya Bashivan and Anmar Khadra and Maurice J Chacron

Iscience, 2025

In Vivo Neural Activity of Electrosensory Pyramidal Cells: Biophysical Characterization and Phenomenological Modeling

Amin Akhshi and Michael G Metzen and Maurice J Chacron and Anmar Khadra

PLoS Computational Biology, 2025

GluA2-Containing AMPA Receptors form a Continuum of Ca2+-Permeable Channels

Federico Miguez-Cabello and Xin-tong Wang and Yuhao Yan and Niklas Brake and Ryan P. D. Alexander and Amanda M. Perozzo and Anmar Khadra & Derek Bowie

Nature, 2025

Deciphering Heterogeneity of ATP-Induced Ca2+ Responses in Osteoblasts Using the Flux-Balance Model

Anthony Quint and Nicholas Mikolajewicz and Svetlana V Komarova and Anmar Khadra

International Conference on Applied Mathematics, Modeling and Computational Science. Cham: Springer Nature Switzerland, 2025

A neurophysiological basis for aperiodic EEG and the background spectral trend

Niklas Brake and Flavie Duc and Alexander Rokos and Francis Arseneau and Shiva Shahiri and Anmar Khadra and Gilles Plourde

Nature communications, 2024

Characterization of common genetic variants in P2RX7 and their contribution to chronic pain conditions

Katerina Zorina-Lichtenwalter and Ariel R Ase and Vivek Verma and Arturo IM Parra and Svetlana Komarova and Anmar Khadra and Philippe Séguéla and Luda Diatchenko

The Journal of Pain, 2024

Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity

Hassan Jamaleddine and Dakota Rogers and Geneviève Perreault and Jérémy Postat and Dhanesh Patel and Judith N Mandl and Anmar Khadra

Plos Biology, 2024

Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells

Hooman Bagheri and Hana Friedman and Amanda Hadwen and Celia Jarweh and Ellis Cooper and Lawrence Oprea and Claire Guerrier and Anmar Khadra and Armand Collin and Julien Cohen‐Adad and Amanda Young and Gerardo Mendez Victoriano and Matthew Swire and Andrew Jarjour and Marie E Bechler and Rachel S Pryce and Pierre Chaurand and Lise Cougnaud and Dajana Vuckovic and Elliott Wilion and Owen Greene and Akiko Nishiyama and Anouk Benmamar‐Badel and Trevor Owens and Vladimir Grouza and Marius Tuznik and Hanwen Liu and David A Rudko and Jinyi Zhang and Katherine A Siminovitch and Alan C Peterson

Glia, 2024

Neural Signaling in neuropathic pain: A computational modeling perspective

Xinyue Ma and Anmar Khadra

2024

The influence of circadian rhythms on CD8+ T cell activation upon vaccination: a mathematical modeling perspective

Nasri Balit and Nicolas Cermakian and Anmar Khadra

Journal of Theoretical Biology, 2024

ElecFeX is a user-friendly toolbox for efficient feature extraction from single-cell electrophysiological recordings

Xinyue Ma and Loïs S Miraucourt and Haoyi Qiu and Mengyi Xu and Erik P Cook and Arjun Krishnaswamy and Reza Sharif-Naeini and Anmar Khadra

Cell Reports Methods, 2024

Modulation of SK channels via calcium buffering tunes intrinsic excitability of parvalbumin interneurons in neuropathic pain: A computational and experimental investigation

Xinyue Ma and Loïs S Miraucourt and Haoyi Qiu and Reza Sharif-Naeini and Anmar Khadra

Journal of Neuroscience, 2023

Polarity and mixed-mode oscillations may underlie different patterns of cellular migration

Lucie Plazen and Jalal Al Rahbani and Claire M Brown and Anmar Khadra

Scientific Reports, 2023

Visual attention to features and space in mice using reverse correlation

J Lehnert and K Cha and J Halperin and K Yang and DF Zheng and A Khadra and EP Cook and A Krishnaswamy.

Current Biology, 2023

Excitable dynamics in a molecularly-explicit model of cell motility: Mixed-mode oscillations and beyond

Lucie Plazen and Anmar Khadra

Journal of Theoretical Biology, 2023

Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis

You Chi Tang and Khoren Ponsin and Adda-Lee Graham-Paquin and Carole Luthold and Kevin Homsy and Magdalena Schindler and Viviane Tran and Jean-François Côté and François Bordeleau and Anmar Khadra and Maxime Bouchard

Cell Reports, 2023

Theoretical Quantification of the Polyvalent Binding of Nanoparticles Coated with Peptide-MHC to TCR-Nanoclusters

Manuela Pineros-Rodriguez and Louis Richez and Anmar Khadra

Mathematical Biosciences, 2023

Characterizing spontaneous Ca2+ local transients in OPCs using computational modeling

Lawrence Oprea and Nicolas Desjardins and Xiaoyu Jiang and Kushagra Sareen and James Q Zheng and Anmar Khadra

Biophysical Journal, 2022

Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

Niklas Brake and Adamo S Mancino and Yuhao Yan and Takushi Shimomura and Yoshihiro Kubo and Anmar Khadra and Derek Bowie

Journal of General Physiology, 2022

Calcium buffering tunes intrinsic excitability of spinal dorsal horn parvalbumin-expressing interneurons: A computational model

Xinyue Ma

2022

Characterizing spontaneous Ca2+ local transients in OPCs using computational modeling

Laurentiu Oprea and Nicolas Desjardins and Xiaoyu Jiang and Kushagra Sareen and James Q Zheng and Anmar Khadra

Biophysical Journal, 2022

High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts

Nicholas Mikolajewicz and Delaney Smith and Svetlana V Komarova and Anmar Khadra

PLoS computational biology, 2021

Deciphering the dynamics of lamellipodium in a fish keratocytes model

Laurent MacKay and Etienne Lehman and Anmar Khadra

Journal of Theoretical Biology, 2021

Aperiodic EEG activity masks the dynamics of neural oscillations during loss of consciousness from propofol

Niklas Brake and Flavie Duc and Alexander Rokos and Francis Arseneau and Shiva Shahiri and Anmar Khadra and Gilles Plourde

bioRxiv, 2021

Gonadotrophin‐releasing hormone and kisspeptin: it takes two to tango

Anne Duittoz and Xavier Cayla and Renaud Fleurot and Jonas Lehnert and Anmar Khadra

2021

Intrinsic gating behavior of voltage-gated sodium channels predetermines regulation by auxiliary β-subunits

Niklas Brake and Adamo S Mancino and Yuhao Yan and Takushi Shimomura and Heika Silveira and Yoshihiro Kubo and Anmar Khadra and Derek Bowie

bioRxiv, 2021

HLA polymorphisms and food allergy predisposition

Maria Kostara and Vasiliki Chondrou and Argyro Sgourou and Konstantinos Douros and Sophia Tsabouri

2020

The bioenergetics of integrin-based adhesion, from single molecule dynamics to stability of macromolecular complexes

Laurent MacKay and Anmar Khadra

2020

Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding

Saeed Farjami and Ryan PD Alexander and Derek Bowie and Anmar Khadra

PLOS Computational Biology, 2020

Quantifying immunoregulation by autoantigen‐specific T‐regulatory type 1 cells in mice with simultaneous hepatic and extra‐hepatic autoimmune disorders

Hassan Jamaleddine and Pere Santamaria and Anmar Khadra

Immunology, 2020

Modeling excitability in cerebellar stellate cells: Temporal changes in threshold, latency and frequency of firing

John Mitry and Ryan PD Alexander and Saeed Farjami and Derek Bowie and Anmar Khadra

Communications in Nonlinear Science and Numerical Simulation, 2020

Machine classification of spatiotemporal patterns: automated parameter search in a rebounding spiking network

Lawrence Oprea and Christopher C Pack and Anmar Khadra

Cognitive neurodynamics, 2020

Switching in cerebellar stellate cell excitability in response to a pair of inhibitory/excitatory presynaptic inputs: a dynamical system perspective

Saeed Farjami and Ryan PD Alexander and Derek Bowie and Anmar Khadra

Neural Computation, 2020

Immune-cell dynamics in type 1 diabetes

Hassan Jamaleddine and Anmar Khadra

2020

Relative Voltage Sensor Activation Kinetics Determines the Effects of Sensor Neutralization in Voltage-Gated Sodium Channels

Niklas Brake and Adamo Mancino and Yuhao Yan and Takushi Shimomura and Yoshihiro Kubo and Derek Bowie and Anmar Khadra

Biophysical Journal, 2020

Diabetes Systems Biology: Quantitative methods for understanding beta-cell dynamics and function

Anmar Khadra

2020

Understanding Mechanical Effects on the Dynamics of Nascent Adhesions

Laurent MacKay and Etienne Lehman and Anmar Khadra

Biophysical Journal, 2020

Cerebellar stellate cell excitability is coordinated by shifts in the gating behavior of voltage-gated Na+ and A-type K+ channels

Ryan PD Alexander and John Mitry and Vasu Sareen and Anmar Khadra and Derek Bowie

Eneuro, 2019

Rac activation is key to cell motility and directionality: an experimental and modelling investigation

Jessica K Lyda and Zhang L Tan and Abira Rajah and Asheesh Momi and Laurent Mackay and Claire M Brown and Anmar Khadra

Computational and structural biotechnology journal, 2019

How pulsatile kisspeptin stimulation and GnRH autocrine feedback can drive GnRH secretion: a modeling investigation

Jonas Lehnert and Anmar Khadra

Endocrinology, 2019

Dynamics of mechanosensitive nascent adhesion formation

Laurent MacKay and Anmar Khadra

Biophysical journal, 2019

Paxillin phosphorylation at serine 273 and its effects on Rac, Rho and adhesion dynamics

Kaixi Tang and Colton G Boudreau and Claire M Brown and Anmar Khadra

PLoS computational biology, 2018

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

Santiswarup Singha and Kun Shao and Yang Yang and Xavier Clemente-Casares and Patricia Solé and Antonio Clemente and Jesús Blanco and Qin Dai and Fayi Song and Shang Wan Liu and Jun Yamanouchi and Channakeshava Sokke Umeshappa and Roopa Hebbandi Nanjundappa and Pascal Detampel and Matthias Amrein and César Fandos and Robert Tanguay and Susan Newbigging and Pau Serra and Anmar Khadra and Warren CW Chan and Pere Santamaria

Nature nanotechnology, 2017

Deciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models

Laurent Mackay and Hana Zemkova and Stanko S Stojilkovic and Arthur Sherman and Anmar Khadra

PLoS computational biology, 2017

Systematic characterization of dynamic parameters of intracellular calcium signals

Laurent Mackay and Nicholas Mikolajewicz and Svetlana V Komarova and Anmar Khadra

Frontiers in physiology, 2016

A unified model for two modes of bursting in GnRH neurons

Spencer Moran and Suzanne M Moenter and Anmar Khadra

Journal of computational neuroscience, 2016

Mathematical model of galactose regulation and metabolic consumption in yeast

Tina M. Mitre and Mackey Michael C. and Anmar Khadra

Journal of Theoretical Biology, 2016

The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: A modeling investigation

Tina M Mitre and Massimo Pietropaolo and Anmar Khadra

Mathematical Biosciences, 2016

05 Sexual health awareness amongst university undergraduate students

A Khadra

The Journal of Sexual Medicine, 2016

Immunogenetics of type 1 diabetes mellitus

Michael P Morran and Andrew Vonberg and Anmar Khadra and Massimo Pietropaolo

2015

Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention

Aaron Michels and Li Zhang and Anmar Khadra and Jake A Kushner and Maria J Redondo and Massimo Pietropaolo

2015

Development, growth and maintenance of β-cell mass: Models are also part of the story

Anmar Khadra and Santiago Schnell

2015

Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes

Majid Jaberi-Douraki and Santiago Schnell and Massimo Pietropaolo and Anmar Khadra

Journal of theoretical biology, 2015

Allosteric regulation of the P2X4 receptor channel pore dilation

Hana Zemkova and Anmar Khadra and Milos B Rokic and Vendula Tvrdonova and Arthur Sherman and Stanko S Stojilkovic

Pflügers Archiv-European Journal of Physiology, 2015

Continuum model of T-cell avidity: understanding autoreactive and regulatory T-cell responses in type 1 diabetes

Majid Jaberi-Douraki and Massimo Pietropaolo and Anmar Khadra

Journal of theoretical biology, 2015

Autoimmune responses in T1DM: quantitative methods to understand onset, progression, and prevention of disease

Majid Jaberi‐Douraki and Shang Wan Liu and Massimo Pietropaolo and Anmar Khadra

2014

Predictive models of type 1 diabetes progression: understanding T-cell cycles and their implications on autoantibody release

Majid Jaberi-Douraki and Massimo Pietropaolo and Anmar Khadra

PloS one, 2014

Deciphering the kinetic and gating properties of purinergic P2X7 receptor channels

Laurent Mackay and Arthur Sherman and Stanko S Stojilkovic and Anmar Khadra

Athens Journal of Natural & Formal Sciences, 2014

Predictive Models of Type 1 Diabetes Progression: Understanding T-Cell Cycles and Their Implications

M Jaberi-Douraki and M Pietropaolo and A Khadra

PLoS One, 2014

Dual gating mechanism and function of P2X7 receptor channels

Anmar Khadra and Melanija Tomić and Zonghe Yan and Hana Zemkova and Arthur Sherman and Stanko S Stojilkovic

Biophysical journal, 2013

Quantifying the importance of pMHC valency, total pMHC dose and frequency on nanoparticle therapeutic efficacy

Jordan Sugarman and Sue Tsai and Pere Santamaria and Anmar Khadra

Immunology and cell biology, 2013

Gating properties of the P2X2a and P2X2b receptor channels: experiments and mathematical modeling

Anmar Khadra and Zonghe Yan and Claudio Coddou and Melanija Tomić and Arthur Sherman and Stanko S Stojilkovic

Journal of General Physiology, 2012

Understanding the Kinetics of ATP-Activated P2X2A and P2X2B Receptor Channels using a Markov State Model

Anmar Khadra

Biophysical Journal, 2012

Calcium-dependent block of P2X7 receptor channel function is allosteric

Zonghe Yan and Anmar Khadra and Arthur Sherman and Stanko S Stojilkovic

Journal of General Physiology, 2011

Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction

Anmar Khadra and Massimo Pietropaolo and Gerald T Nepom and Arthur Sherman

PloS one, 2011

Experimental characterization and mathematical modeling of P2X7 receptor channel gating

Zonghe Yan and Anmar Khadra and Shuo Li and Melanija Tomić and Arthur Sherman and Stanko S Stojilkovic

Journal of Neuroscience, 2010

Unified impulsive fuzzy-model-based controllers for chaotic systems with parameter uncertainties via LMI

Xiaohong Zhang and Anmar Khadra and Dan Yang and Dong Li

Communications in Nonlinear Science and Numerical Simulation, 2010

On how monospecific memory-like autoregulatory CD8+ T cells can blunt diabetogenic autoimmunity: a computational approach

Anmar Khadra and Sue Tsai and Pere Santamaria and Leah Edelstein-Keshet

The Journal of Immunology, 2010

The pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach

Anmar Khadra and Pere Santamaria and Leah Edelstein-Keshet

International immunology, 2010

Analyzing the robustness of impulsive synchronization coupled by linear delayed impulses

Anmar Khadra and Xinzhi Z Liu and Xuemin Shen

IEEE Transactions on Automatic Control, 2009

Impulsive stability of chaotic systems represented by TS model

Xiaohong Zhang and Anmar Khadra and Dong Li and Dan Yang

Chaos, Solitons & Fractals, 2009

The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation

Anmar Khadra and Pere Santamaria and Leah Edelstein-Keshet

Journal of theoretical biology, 2009

Synchrony due to parametric averaging in neurons coupled by a shared signal

Anmar Khadra

Physica D: Nonlinear Phenomena, 2009

Analysis and design for unified exponential stability of three different impulsive T–S fuzzy systems

Xiaohong Zhang and Anmar Khadra and Dan Yang and Dong Li

Chaos, Solitons & Fractals, 2009

995 PREDICTORS OF PENILE CANCER RECURRENCE FOLLOWING CONSERVATIVE SURGICAL RESECTION

GM Brown and A Khadra and A Abdelraheem and G Garaffa and A Freeman and R Rees and A Muneer and DJ Ralph and S Minhas

European Urology Supplements, 2009

The new 120W GreenLight High Performance System (HPS) laser-is it an effective tool in the treatment of the symptomatic benign prostate?

BE Ayres and A Khadra and M Davies and C Brown and NJ Barber

2009

1002 THE OUTCOME OF PENILE PROSTHETIC REVISION SURGERY

G Garaffa and S Minhas and A Khadra and G Brown and Raheem AM Abdel and A Muneer and AN Christopher and DJ Ralph

European Urology Supplements, 2009

996 TOTAL PHALLIC RECONSTRUCTION USING THE RADIAL ARTERY FOREARM FREE FLAP FOLLOWING AMPUTATION FOR PENILE CANCER

G Garaffa and GM Brown and A Khadra and Raheem AM Abdel and A Muneer and S Minhas and AN Christopher and DJ Ralph

European Urology Supplements, 2009

Penile reconstruction for benign disease with the use of skin grafting

G Garaffa and A Raheem and A Khadra and E Zacharakis and S Minchas and A Muneer and N Christopher and D Ralph

J SEX MED, 2009

Robust synchrony and rhythmogenesis in endocrine neurons via autocrine regulations in vitro and in vivo

Yue-Xian Li and Anmar Khadra

Bulletin of mathematical biology, 2008

A model for the pulsatile secretion of gonadotropin-releasing hormone from synchronized hypothalamic neurons

Anmar Khadra and Yue-Xian Li

Biophysical journal, 2006

Impulsively synchronizing chaotic systems with delay and applications to secure communication

Anmar Khadra and XZ Liu and Xuemin Shen

Automatica, 2005

Impulsive control and synchronization of spatiotemporal chaos

Anmar Khadra and Xinzhi Liu and Xuemin Shen

Chaos, Solitons & Fractals, 2005

Impulsive control and synchronization of chaos-generating-systems with applications to secure communication

Anmar Khadra

2004

Testicular self awareness of men with intellectual disabilities (ID): Randomised control trial of health promotion interventions

J Wilson and P Adeline and J Bernal and D Bungaroo and A Khadra and S Hollins

2004

Application of impulsive synchronization to communication security

Anmar Khadra and Xinzhi Liu and Xuemin Shen

IEEE Transactions on Circuits and Systems I: Fundamental Theory and Applications, 2003

Robust impulsive synchronization and application to communication security

Anmar Khadra and Xinzhi Liu and Xuemin Shen

DYNAMICS OF CONTINUOUS DISCRETE AND IMPULSIVE SYSTEMS SERIES B, 2003

Maximization of Areas Defined by Binary Forms: Cyclic Functions and Other Approaches

Anmar Khadra

1999

Excitable dynamics in a molecularly-explicit model of cell motility: Mixed-mode oscillations and beyond Manuscript

Lucie Plazen and Anmar Khadra

Polarity and mixed-mode oscillations may underlie different patterns of cellular migration MAnUsCRiPt

Lucie Plazen and Jalal Al Rahbani and Claire M Brown and Anmar Khadra

Understanding How Differences in Morphology, Intrinsic Properties, and Extrinsic Synaptic Input Shape Spiking Activity in Sensory Neural Populations in vivo

Amin Akhshi and Myriah Haggard and Mariana M Marquez and Saeed Farjami and Maurice J Chacron and Anmar Khadra

Intrinsic Properties, and Extrinsic Synaptic Input Shape Spiking Activity in Sensory Neural Populations in vivo,

Mechanical Control of Epithelial Tissue Morphogenesis by Apoptosis and Non-Professional Efferocytosis

You Chi Tang and Khoren Ponsin and Adda-Lee Graham-Paquin and Magdalena Schindler and Carole Luthold and Viviane Tran and Jean-François Côté and François Bordeleau and Anmar Khadra and Maxime Bouchard

Available at SSRN 3919937,

APPENDIX S1: PREDICTIVE MODELS OF TYPE 1 DIABETES PROGRESSION: UNDERSTANDING T-CELL CYCLES AND THEIR IMPLICATIONS ON AUTOANTIBODY RELEASE

MAJID JABERI-DOURAKI and MASSIMO PIETROPAOLO and ANMAR KHADRA

Supplementary Information: A unified model for two modes of bursting in GnRH neurons

Spencer Moran and Suzanne M Moenter and Anmar Khadra

ADAPTATIONS OF THE GALACTOSE METABOLISM AND GENE NETWORK TO CHANGES IN EXTRACELLULAR GALACTOSE AND GLUCOSE

Tina M Mitre and Michael C Mackey and Anmar Khadra

ATINER's Conference Paper Series

Laurent Mackay and Arthur Sherman and Stanko S Stojilkovic and Anmar Khadra